The combustion and heat transfer characteristics of a hydrogen-fueled microreactor are investigated experimentally and numerically. The microreactor comprises a 30×30×4 mm^3 SiC-block equipped with six 1.5 mm diameter platinum channels. Combustion of fuel-lean H2/air mixtures at equivalence ratios φ = 0.25-0.50 and inlet velocities 15–50 m/s is studied at coflow and counter-flow configurations. Surface temperatures are measured with an infrared camera, while simulations are carried out with a 3D code that includes conjugate heat transfer, appropriate external heat losses, and detailed hetero-/homogeneous chemistry. Higher mass throughputs reduce the surface temperature spatial non-uniformities, while the onset of gaseous combustion lowers the catalyst surface temperatures and is thus detrimental for power generation applications. Four different channel configurations are tested for optimum temperature uniformity. Counterflow configurations are shown superior to the coflow configuration in attaining better surface temperature uniformities with standard deviations less than 19 K and maximum surface temperatures up to 1311 K. Comparisons of measurements and predictions are very favorable in terms of temperature probability density function (PDF) shapes and higher distribution moments. Counterflow configurations yield narrower PDFs slightly skewed to the low temperatures, while the coflow configuration yields mostly bimodal shapes. Radiation efficiencies increase with increasing inlet velocity and equivalence ratio. Application of the microreactor to power generation systems, in conjunction with thermoelectric devices, appears quite promising given the attained good spatial uniformity and the high values of surface temperatures.